Both Cobalamin and Mecobalamin are active coenzyme forms of vitamin B12, and the cells in the body can convert either form of vitamin B12 to their own needs, so the function of either type of vitamin B12 is basically the same, but there are some differences.
Structural differences: Mecobalamine connects to methyl at the central cobalt molecule, whereas Cobalamin connects to 5-deoxyribose adenosine.
The difference in drug efficacy: Although both are coenzyme B12, and both are involved in biochemical reactions in the body, there are 12 biochemical reactions in the body that require Cobalamin, and there is only one biochemical reaction that requires Mecobalamine, and it is this biochemical reaction that is closely related to the activity of nerve tissue, So Mecobalamine is the best vitamin B12 for nerve disorders.
Clinical application: Since Cobalamin is easily destroyed in the digestive tract, the clinical dosage form is injection (Cobalamin powder). Mecobalamine is commonly taken orally.
Post time: Mar-12-2023
