Luteolin, mostly in the form of glycoside exists in a variety of plants, these plants in the whole leaf blue orchid, pepper, wild chrysanthemum, honeysuckle, Perilla high content.
Luteolin has antitussive and expectorant effects. According to the latest research, respiratory symptoms cough, expectoration, wheezing, and chronic airway inflammation. Such as bronchial asthma, chronic obstructive pulmonary disease, chronic pharyngitis, allergic rhinitis and other causes of cough, expectoration, wheezing, are considered to be related to local inflammatory infiltration, the existence of inflammation, make the airway immune response chaos, patients often appear airway responsiveness. Treatment should first eliminate chronic inflammatory infiltration of the airways. Glucocorticoids are commonly used to reduce airway inflammation. However, glucocorticoid has more side effects and should not be used for a long time.
Studies have shown that luteolin inhibits the phosphorylation of macrophages, inhibits the activity of transcription factor NF-KB, and inhibits the production of cytokines IL-6 and TNF-A in LPS induced macrophages. The latter two cytokines play a very important role in the mechanism of inflammation and are sensitive indicators reflecting the degree of inflammation. Luteolin can also increase IFN-γ, decrease specific IG-E, and reduce eosinophil infiltration. In addition, luteolin not only has anti-inflammatory and anti-allergic effects, but also has anti-PDE, anti-SARS and ANTI-HIV properties. The reason is that it inhibits the activity of SARS virus pre-S protein, thus preventing it from entering host cells. For the treatment of COPD, bronchial asthma, as well as chronic pharyngitis, allergic rhinitis caused by chronic cough.
Post time: Apr-05-2022
