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Application of Xanthohumol

Application of Xanthohumol

Hops are by far the only source of natural xanthohumol. Xanthohumol containing produced by the hops gland in hops isoprene based, chalcone but its inherent biological characteristics make its in beer brewing could happen after the heterogeneous form different xanthohumol to alter its corresponding biological activities.

1. Xanthohumol inhibits the proliferation of human prostate cancer PC3 cells

Western blot was used to detect cell cycle and cell apoptosis to analyze the biological activity of xanthohumol in hops on THE proliferation of PC3 cells. The experiment showed that xanthohumol could inhibit the proliferation of PC3 cells.

2. Antiviral effect of xanthohumol

Buckwold showed that xanthohumol had an inhibitory effect on ruminant dysentery virus (BVDV) herpes simplex virus 1(HSV-1) and herpes simplex virus 2(HSV-12).In addition, Wang et al. found that xanthohumol has an inhibitory effect on HIV 1.Louis et al. studied the inhibitory effect of xanthohumol on hepatitis C virus and found that xanthohumol could significantly inhibit the RNA level of hepatitis C virus at 3.53 U mol.L-1, indicating that xanthohumol had biological activity against hepatitis C virus.

3, antioxidant biological activity of xanthohumol in hops

The polyphenolic flavonoids in hops were mainly chalcone substances such as xanthohumol, followed by flavonoids such as actilin, quercetin, myricetin and flavonols.Flavonoids and polyphenols have strong ability to capture free radicals and antioxidant activity.


Post time: Sep-08-2021

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